The thyroid gland produces thyroid hormone (TH) by synthesizing it through the iodination of tyrosine residues in the glycoprotein thyroglobulin. TH regulates metabolic processes necessary for average growth and development and for maintaining adult metabolism. TH level in the body influences body weight and energy expenditure. Low TH levels can reduce cardiac output, increase systemic vascular resistance, and impair immune function, possibly delaying injury repair. Compared to pharmacological options to manage thyroid imbalance that have adverse side effects, nutraceuticals, such as selenium, zinc, myo-inositol, and N-Acetyl-L-cysteine are valuable to tackle thyroid complications and have fewer side effects on general health.